Açık Erişim Sistemine Hoş Geldiniz

Bursa Uludağ Üniversitesi, bilimin ve teknolojinin ilerlemesine katkı sağlamayı, açık, tekrarlanabilir ve güvenilir araştırma çıktıları ile uygulamalarını benimseyerek; toplum ve tüm dış paydaşları yararına bilginin geniş yayılımını taahhüt eder.

BUU Açık Erişim Sistemi, öğretim üyelerimiz ve öğrencilerimizin uluslararası standartlara ve fikri mülkiyet haklarına uygun olarak ürettikleri kitap, makale, tez, ansiklopedi, sanat eseri gibi bilimsel ve sanatsal ürünleri sunmaktadır.

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Transcranial Microsurgery as a Salvage Strategy in Giant Pituitary Adenomas: A Single-Center Experience and Long-Term Follow-up Results.
(2025) Altunyuva, Oguz; Ozmarasali, Ali Imran; Balcin, Nur; Unal, Hanside Setenay; Yilmazlar, Selcuk
Endoscopic transsphenoidal surgery (ETSS) is the preferred approach for most pituitary adenomas. However, transcranial microsurgery remains relevant for giant adenomas with complex features. This study presents long-term outcomes and complications in a single-surgeon series of patients with giant pituitary adenomas who underwent transcranial resection.
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[MSB-10] The Biomarker Potential of Serum-Derived Exosomes Carrying Autophagic Regulators in Carotid Artery Stenosis Patients.
(2024-11) Colakoglu Bergel, Ceyda; Eryilmaz, Isil Ezgi; Arioz, Bilge; Yolgosteren, Atif; Egeli, Unal; Erdemli Gursel, Basak; Bicer, Murat; Cecener, Gulsah; Tok, Mustafa
This study aimed to investigate the biomarker potential of exosomes as autophagic regulators for discriminating ulcerated from smooth ones by serum-derived exosome isolation and real-time quantitative polymerase chain reaction (RT-qPCR) analysis.
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Eyelid mass from cutaneous leishmaniasis: Skin-sparing surgical excision
(2025-10-23) Yazici, Bulent; Erseven, Cansu; Adim, Saduman B.; BALABAN ADIM, ŞADUMAN; Tıp Fakültesi; Tıbbi Patoloji Ana Bilim Dalı; 0000-0002-5039-164X
A 28-year-old male presented with a 22 × 12 mm erythematous mass in his right upper eyelid for 1 year. The lesion clinically resembled a malignant neoplasm, but incisional biopsy revealed cutaneous leishmaniasis. To minimize potential scarring, the mass was excised without removing the overlying skin. The lesion was confined anterior to the orbital septum. Postoperatively, the patient received meglumine antimoniate for 15 days, with a rapid and uncomplicated recovery. Although rare, cutaneous leishmaniasis can mimic malignant eyelid tumors. In such cases, skin-sparing excision may offer a viable and effective treatment option.
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Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview
(2025-09-06) Demirel, Sadettin; Sinag, Ipek Nazli; DEMİREL, SADETTİN; Sınağ, İpek Nazlı; Tıp Fakültesi; Fizyoloji Ana Bilim Dalı
Lung cancer is the most frequent cause of cancer-related mortality worldwide. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) participate in numerous physiological processes. These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. NO is a gaseous free radical with tumoricidal and tumorigenic activities in lung cancer. Arachidonic acid-derived PGs, including PGD, PGE, 8-iso-PGF, and PGI, are related to the development of lung cancer. PGD and PGI act as tumor suppressors, while PGE and 8-iso-PGF promote tumor progression. TXA catalyzed by cyclooxygenase induces proliferation as well as angiogenesis. Elevated levels of TXB, an inactive metabolite of TXA, are positively correlated with lung carcinoma stages. ET-1 and ET-2 are 21 amino acid polypeptides; their silencing hinders lung cancer cell proliferation and invasion. ET-2 depletion also triggers apoptotic death. This chapter review aims to provide a comprehensive overview of the role of NO, PGs, TXs, and ETs in lung cancer.
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Multidisciplinary Team Management of Hepatocellular Carcinoma in the MENA Region: Current Practices, Challenges, and Gaps.
(2025) El-Kassas, Mohamed; Khalifa, Rofida; AlNaamani, Khalid M; Shousha, Hend; Yilmaz, Yusuf; Sanai, Faisal M; Almattooq, Maen; Labidi, Asma; Akroush, Maisam W I; Debzi, Nabil; Abdelmalek, Mohamed Omar; Abdeen, Nermeen Sherif; Tumi, Ali; Elbadry, Mohamed; El Fouly, Amr; Marwan, Eman; Al Suwaidi, Jassim; Elzouki, Abdel-Naser; Alswat, Khalid A
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a high disease burden in the Middle East and North Africa (MENA) region. Multidisciplinary teams (MDTs) are essential for optimizing HCC management; however, their implementation and impact may vary across healthcare settings. This study evaluates the structure, decision-making processes, and challenges faced by MDTs in HCC treatment centers across the MENA region.